colon carcinoma — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2676	PF-04217903		c-Met/HGFR
	MET Tyrosine Kinase Inhibitor PF-04217903 is an orally bioavailabe, small-molecule tyrosine kinase inhibitor with potential antineoplastic activity.		c-Met/HGFR
T28410	PHPS1	PHPS-1,PHPS 1	Phosphatase
	PHPS1 is an inhibitor of Shp2. PHPS1 efficiently inhibits activation of Erk1/2 by the leukemia-associated Shp2 mutant, Shp2-E76K, and blocks the anchorage-independent growth of a variety of human tumor cell lines.		Phosphatase
T5S1133	Ganoderic acid D		Apoptosis , Sirtuin
	1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervical carcinoma cells with an IC(5) value of 17.3 +/- .3 micr...		Apoptosis , Sirtuin
T6609	NMS-E973		HSP
	NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.		HSP
T2455	PFK-015	PFK15,PFK 015	Glucokinase , Autophagy
	PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).		Glucokinase , Autophagy
T19147	5-ALA benzyl ester hydrochloride	Benzyl-ALA hydrochloride	Others , Endogenous Metabolite
	5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) is a protoporphyrin precursor. 5-ALA benzyl ester hydrochloride is used as a photodetection agent. 5-ALA benzyl ester hydrochloride could induce protoporphyrin ...		Others , Endogenous Metabolite
TQ0157	EIPA	L593754,MH 12-43	Sodium Channel , TRP/TRPV Channel
	EIPA (L593754) (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.		Sodium Channel , TRP/TRPV Channel
T1520	Aliskiren hemifumarate	CGP 60536,SPP 100,CGP60536B	RAAS , Autophagy
	Aliskiren hemifumarate (CGP60536B) is an orally active nonpeptide renin inhibitor with antihypertensive activity.		RAAS , Autophagy
T1709	2'-Deoxyinosine	Guanine deoxyriboside,Deoxyinosine	Others , Endogenous Metabolite
	2'-Deoxyinosine (Guanine deoxyriboside) inhibits the growth of human colon-carcinoma cell lines and is associated with purine nucleoside phosphorylase (PNP) deficiency.		Others , Endogenous Metabolite
T5746	Dictamine	Dictamnine,Dectamine	Apoptosis , Anti-infection , Antibacterial , Antifungal
	Dictamine (Dectamine) shows anticholinesterase, anti-inflammatory, mutagenic, and has antimicrobial activity against bacteria and fungi. It has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma...		Apoptosis , Anti-infection , Antibacterial , Antifungal
T5618	AK-1		Sirtuin
	AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells.		Sirtuin
T5S0506	Rotundic acid	Rutundic acid	Apoptosis , Others , p38 MAPK , Akt , mTOR
	Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) c...		Apoptosis , Others , p38 MAPK , Akt , mTOR
TN1405	Arnicolide D		Akt , Caspase , PI3K , STAT , mTOR
	Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling path...		Akt , Caspase , PI3K , STAT , mTOR
T1660	Silibinin	Silibinin A,Silybin,Silymarin I	Reactive Oxygen Species , Autophagy
	Silibinin (Silybin) is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin an...		Reactive Oxygen Species , Autophagy
T77651	Tubulin polymerization-IN-47		Microtubule Associated
	Tubulin polymerization-IN-47 is a tubulin polymerization inhibitor and mitotic inhibitor with antitumor activity and inhibitory effects on neuroblastoma cancer cell proliferation, with IC50s of 7 and 12 nM for Chp-134 an...		Microtubule Associated
TN2029	P-Hydroxy-5,6-dehydrokawain	4'-Hydroxydehydrokawain	Others
	p-Hydroxy-5,6-dehydrokawain (4'-Hydroxydehydrokawain) is isolated from Kawain.		Others
T40708	Neoanhydropodophyllol
	Neoanhydropodophyllol, a cyclolignan derivative, exhibits potent antineoplastic activity by exerting cytotoxic effects on various cancer cell lines including leukemia, lung carcinoma, and colon carcinoma.
T71912	PD 173955-Analog1
	PD 173955-Analog1 is a potent c-Src inhibitor known to have activity against a variety of cancers including colon, lung, head and neck carcinoma.
T20050	Cinnamamide	NSC 32953
	Cinnamamide is an amide of trans-cinnamic acid and a metabolite of Streptomyces. It also reduced tumor weight in a mouse model of C26 murine colon carcinoma, in vivo.
TN5093	Taiwanhomoflavone A		COX
	Taiwanhomoflavone A is cytotoxic with ED50 values of 3.4, 1.0, 2.0 and 2.5 microg/ml, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 colon carcinoma, Hepa-3B hepatoma, and Hela cervix tumor cells.		COX